A Day On Wikipedia

The ”’International Studies of Infarct Survival”’ (”’ISIS”’) were four [[randomized controlled trial]]s of several [[drug]]s for treating suspected [[acute (medicine)|acute]] [[myocardial infarction]] (‘heart attack’). More than 134,000 patients from over 20 countries took part in four large simple trials between 1981 and 1993, coordinated from [[Oxford]], England.<ref name=Hennekens1998>{{citation
| last1 = Hennekens | first1 = Charles H.
| year = 1998
| title = Trials of Thrombolytic Therapy: the International Studies of Infarct Survival Experience
| journal = Journal of Interventional Cardiology
| volume = 11
| pages = 1
| doi = 10.1111/j.1540-8183.1998.tb00089.x
}}</ref><ref name=Hennekens2005>{{Citation
| last = Hennekens | first = Charles H.
| last2 = Skerrett | first2 = P.J.
| year = 2005
| title = International Studies of Infarct Survival (ISIS)
| doi = 10.1002/0470011815.b2a01031
| journal = Encyclopedia of Biostatistics
}}</ref>

==ISIS-1==
The First International Study of Infarct Survival (ISIS-1) was a [[placebo]]-controlled trial of the [[beta-blocker]] [[atenolol]]. It recruited 16,027 patients and was completed in 1985.<ref>{{citation
| year = 1986
| author = ISIS-1 (Second International Study of lnfarct Survival) Collaborative Group
| title = Randomised trial of intravenous atenolol among 16027 cases of suspected acute myocardial
infarction: ISIS-1
| journal = The Lancet
| volume = 328
| pages = 57-66
| doi = 10.1016/S0140-6736(88)92833-4
}}</ref>

==ISIS-2==
The Second International Study of Infarct Survival (ISIS-2) was a 2×2 [[factorial experiment|factorial]] [[placebo]]-controlled trial of the [[thrombolytic]] drug [[streptokinase]] and [[aspirin]]. It recruited 17,187 patients and was completed in 1988.<ref>{{citation
| year = 1988
| author = ISIS-2 (Second International Study of lnfarct Survival) Collaborative Group
| title = Randomised Trial of Intravenous Streptokinase, Oral Aspirin, Both, or Neither Among 17 187 Cases of Suspected Acute Myocardial Infarction: ISIS-2
| journal = The Lancet
| volume = 332
| pages = 349-360
| doi = 10.1016/S0140-6736(88)92833-4
}}</ref>

==ISIS-3==
The Third International Study of Infarct Survival (ISIS-3) was a 3×2 [[factorial experiment|factorial]] trial that compared the three [[thrombolytic]] drugs [[streptokinase]], [[tissue plasminogen activator]] (tPA) and [[anistreplase]] to each other, and also compared the [[anticoagulant]] [[heparin]] to no heparin. All patients were also given [[aspirin]]. It recruited 41,299 patients and was completed in 1991.<ref name=Isis1992>{{citation
| author = ISIS-3 (Third International Study of lnfarct Survival) Collaborative Group
| year = 1992
| title = ISIS-3: a randomised comparison of streptokinase vs tissue plasminogen activator vs anistreplase and of aspirin plus heparin vs aspirin alone among 41 299 cases of suspected acute myocardial infarction
| journal = The Lancet
| volume = 339
| pages = 753-770
| doi = 10.1016/0140-6736(92)91893-D
}}</ref>

==ISIS-4==
The Fourth International Study of Infarct Survival (ISIS-4) was a 2×2×2 [[factorial experiment|factorial]] [[placebo]]-controlled trial of the [[angiotensin-converting enzyme]] inhibitor ([[ACE inhibitor]]) [[captopril]], [[mononitrate]] and [[magnesium sulphate]]. It recruited 58,050 patients and was completed in 1993.<ref name=Isis1995>{{citation
| author = ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group
| year = 1995
| title = ISIS-4: A randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58 050 patients with suspected acute myocardial infarction
| journal = The Lancet
| volume = 345
| pages = 669-682
| doi = 10.1016/S0140-6736(95)90865-X
}}</ref>

==See also==
*[[GISSI]]
*[[Thrombolysis In Myocardial Infarction]] (TIMI)

==References==
{{reflist}}

[[Category:clinical trials]]
[[Category:Interventional cardiology]]

{{med-stub}}

The ”'[[DFB-Pokal|DFB Cup]] 1965”’ was the 22^nd season of the competition. It began on [[January 16]] [[1965]] and ended on [[May 22]] [[1965]]. 32 teams competed in the tournament of five rounds. In the final [[Borussia Dortmund]] defeated [[Alemannia Aachen]] 2 – 0.<ref>{{cite web | title = DFB-Pokal 1964-65 | publisher = fussballdaten.de | accessdate = 2008-10-01 | date = [[2008]] | url = http://www.fussballdaten.de/dfb/1965/ | language = German}}</ref>

== 1^st Round ==

{| width=100% cellspacing=1
!width=25%|
!width=10%|
!width=25%|
!
|-
| [[January 16]] [[1965]]
|- style=font-size:90%
| align=right| ”'[[1. FC Nuremberg]]”’
| align=center| ”’2 – 0”’
| [[1. FC Köln]]
|- style=font-size:90%
| align=right| ”'[[Rot-Weiß Oberhausen]]”’
| align=center| ”’5 – 0”’
| [[TSG Ulm 1846]]
|- style=font-size:90%
| align=right| ”'[[1. FC Kaiserslautern]]”’
| align=center| ”’3 – 0”’
| [[Karlsruher SC]]
|- style=font-size:90%
| align=right| [[Westfalia Herne]]
| align=center| ”’3 – 4”’
| ”'[[Tennis Borussia Berlin]]”’
| ”([[Extra time|AET]])”
|- style=font-size:90%
| align=right| [[VfR Frankenthal]]
| align=center| ”’0 – 5”’
| ”'[[VfB Stuttgart]]”’
|- style=font-size:90%
| align=right| [[Altonaer FC 93]]
| align=center| ”’0 – 5”’
| ”'[[Hannover 96]]”’
|- style=font-size:90%
| align=right| [[Hertha BSC]]
| align=center| ”’1 – 5”’
| ”'[[Eintracht Braunschweig]]”’
|- style=font-size:90%
| align=right| [[VfL Wolfsburg]]
| align=center| ”’3 – 4”’
| ”'[[TSV 1860 München]]”’
|- style=font-size:90%
| align=right| [[Preußen Münster]]
| align=center| ”’0 – 1”’
| ”'[[Borussia Dortmund]]”’
|- style=font-size:90%
| align=right| [[VfL Osnabrück]]
| align=center| ”’1 – 3”’
| ”'[[Alemannia Aachen]]”’
|- style=font-size:90%
| align=right| ”'[[1. FSV Mainz 05]]”’
| align=center| ”’1 – 0”’
| [[SV Werder Bremen]]
|- style=font-size:90%
| align=right| [[KSV Hessen Kassel]]
| align=center| ”’0 – 2”’
| ”'[[Hamburger SV]]”’
|- style=font-size:90%
| align=right| [[SuS Northeim]]
| align=center| ”’0 – 1”’
| ”'[[Meidericher SV]]”’
| ”([[Extra time|AET]])”
|- style=font-size:90%
| align=right| [[TSV Schwaben Augsburg]]
| align=center| ”’5 – 7”’
| ”'[[FC Schalke 04]]”’
| ”([[Extra time|AET]])”
|- style=font-size:90%
| align=right| ”'[[Eintracht Frankfurt]]”’
| align=center| ”’2 – 1”’
| [[Borussia Neunkirchen]]
|- style=font-size:90%
| align=right| [[Kickers Offenbach]]
| align=center| ”’2 – 4”’
| [[VfR Wormatia Worms]]
|}

== 2^nd Round ==

{| width=100% cellspacing=1
!width=25%|
!width=10%|
!width=25%|
!
|-
| [[February 6]] [[1965]]
|- style=font-size:90%
| align=right| [[Eintracht Frankfurt]]
| align=center| ”’1 – 2”’
| ”'[[FC Schalke 04]]”’
|- style=font-size:90%
| align=right| [[1. FSV Mainz 05]]
| align=center| ”’2 – 2”’
| [[TSV 1860 München]]
| ”([[Extra time|AET]])”
|- style=font-size:90%
| align=right| [[VfR Wormatia Worms]]
| align=center| ”’0 – 2”’
| ”'[[VfB Stuttgart]]”’
|- style=font-size:90%
| align=right| ”'[[1. FC Nuremberg]]”’
| align=center| ”’3 – 1”’
| [[Hamburger SV]]
|- style=font-size:90%
| align=right| [[1. FC Kaiserslautern]]
| align=center| ”’1 – 3”’
| ”'[[Hannover 96]]”’
|- style=font-size:90%
| align=right| [[Meidericher SV]]
| align=center| ”’0 – 1”’
| ”'[[Eintracht Braunschweig]]”’
|- style=font-size:90%
| align=right| [[Tennis Borussia Berlin]]
| align=center| ”’1 – 2”’
| ”'[[Borussia Dortmund]]”’
|- style=font-size:90%
| align=right| [[Rot-Weiß Oberhausen]]
| align=center| ”’0 – 1”’
| ”'[[Alemannia Aachen]]”’
|}

=== Replay ===

{| width=100% cellspacing=1
!width=25%|
!width=10%|
!width=25%|
!
|-
| [[February 17]] [[1965]]
|- style=font-size:90%
| align=right| [[TSV 1860 München]]
| align=center| ”’1 – 2”’
| [[1. FSV Mainz 05]]
|}

== Quarterfinals ==

{| width=100% cellspacing=1
!width=25%|
!width=10%|
!width=25%|
!
|-
| [[February 27]] [[1965]]
|- style=font-size:90%
| align=right| [[Eintracht Braunschweig]]
| align=center| ”’0 – 2”’
| ”'[[Borussia Dortmund]]”’
|- style=font-size:90%
| align=right| ”'[[FC Schalke 04]]”’
| align=center| ”’4 – 2”’
| [[VfB Stuttgart]]
|- style=font-size:90%
| align=right| ”'[[Alemannia Aachen]]”’
| align=center| ”’2 – 1”’
| [[Hannover 96]]
|- style=font-size:90%
| align=right| [[1. FSV Mainz 05]]
| align=center| ”’0 – 3”’
| ”'[[1. FC Nuremberg]]”’
|}

== Semifinals ==

{| width=100% cellspacing=1
!width=25%|
!width=10%|
!width=25%|
!
|-
| [[April 17]] [[1965]]
|- style=font-size:90%
| align=right| ”'[[Borussia Dortmund]]”’
| align=center| ”’4 – 2”’
| [[1. FC Nuremberg]]
|- style=font-size:90%
| align=right| ”'[[Alemannia Aachen]]”’
| align=center| ”’4 – 3”’
| [[FC Schalke 04]]
| ”([[Extra time|AET]])”
|}

== Final ==

{{footballbox|
| date = [[May 22]] [[1965]]
| team1 = [[Borussia Dortmund]]
| score = 2 – 0
| team2 = [[Alemannia Aachen]]
| goals1 = [[Alfred Schmidt|Schmidt]] {{goal|10}}<br/>[[Lothar Emmerich|Emmerich]] {{goal|18}}
| goals2 =
| stadium = [[Niedersachsenstadion]] ([[Hannover]])<br />”’Attendance:”’ 55,000 <br />”’Referee:”’ [[Rudibert Jacobi]] ([[Heidelberg]])
}}

{| width=’100%’
| valign=’top’ width=’50%’|

{| style=’font-size: 90%’ cellspacing=’0′ cellpadding=’0′
| colspan=’4’|”’BV BORUSSIA 09 DORTMUND:”’
|-
!width=’25’| !!width=’25’|
|-
| GK || ”’1”’ || {{flagicon|GER}} [[]]
|-
| DF || ”’ ”’ || {{flagicon|GER}} [[]]
|-
| DF || ”’ ”’ || {{flagicon|GER}} [[]]
|-
| DF || ”’ ”’ || {{flagicon|GER}} [[]]
|-
| DF || ”’ ”’ || {{flagicon|GER}} [[]]
|-
| MF || ”’ ”’ || {{flagicon|GER}} [[]]
|-
| MF || ”’ ”’ || {{flagicon|GER}} [[]]
|-
| MF || ”’ ”’ || {{flagicon|GER}} [[]]
|-
| MF || ”’ ”’ || {{flagicon|GER}} [[]]
|-
| FW || ”’ ”’ || {{flagicon|GER}} [[]]
|-
| FW || ”’ ”’ || {{flagicon|GER}} [[]]
|-
| colspan=3|”’Manager:”’
|-
| colspan=’4’|{{flagicon|GER}} [[Hermann Eppenhoff]]
|}
|
| valign=’top’ width=’50%’|
{| style=’font-size: 90%’ cellspacing=’0′ cellpadding=’0′ align=’center’
| colspan=’4’|”’AACHENER TSV ALEMANNIA:”’
|-
!width=’25’| !!width=’25’|
|-
| GK || ”’1”’ || {{flagicon|GER}} [[]]
|-
| DF || ”’ ”’ || {{flagicon|GER}} [[]]
|-
| DF || ”’ ”’ || {{flagicon|GER}} [[]]
|-
| DF || ”’ ”’ || {{flagicon|GER}} [[]]
|-
| DF || ”’ ”’ || {{flagicon|GER}} [[]]
|-
| MF || ”’ ”’ || {{flagicon|GER}} [[]]
|-
| MF || ”’ ”’ || {{flagicon|GER}} [[]]
|-
| MF || ”’ ”’ || {{flagicon|GER}} [[]]
|-
| MF || ”’ ”’ || {{flagicon|GER}} [[]]
|-
| FW || ”’ ”’ || {{flagicon|GER}} [[]]
|-
| FW || ”’ ”’ || {{flagicon|GER}} [[]]
|-
| colspan=3|”’Manager:”’
|-
| colspan=’4’|{{flagicon|GER}} [[Oswald Pfau]]
|}

|}

== References ==

{{reflist}}

== External links ==

* [http://www.dfb.de/ Official site of the DFB] {{de icon}}
* [http://www.kicker.de/ Kicker.de] {{de icon}}
* [http://www.fussballdaten.de/dfb/1965/ 1965 results at Fussballdaten.de] {{de icon}}
* [http://www.weltfussball.de/spielplan/dfb-pokal-1964-1965/ 1965 results at Weltfussball.de] {{de icon}}

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{{DFB Cup}}

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[[Category:DFB-Pokal|1965]]
[[Category:1965 in football (soccer)]]
[[Category:1965 in Germany]]

[[de:DFB-Pokal 1965]]